In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent

In vivo imaging with a cell-permeable porphyrin-based MRI contrast agent.

Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular analytes, construction of cell-permeable imaging agents remains a challenge. Here we show that a porphyrin-based MRI molecular imaging agent, Mn-(DPA-C(2))(2)-TPPS(3), effectivel...

In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast

A novel MRI contrast agent synthesized by ion exchange method

Objective: In this study, the zeolite-coated iron oxide nanoparticles were evaluated as MRI contrast agent and effect of the nanocomposite synthesis method on MRI contrast was tested. Materials and Methods: Ion exchange method was used for synthesis of iron oxide-zeolite and the as prepared nanocomposite was characterized by XRD, FESEM and TEM. The nanocomposite toxicity in the cell culture, a...

Hydrothermal Synthesis of an Ethiodol Based Ferrofluid as a Potential MRI Contrast Agent

In the present work, stable ferrofluids containing oleic acid capped magnetite nanoparticles were synthesized via low temperature hydrothermal method. The physical and chemical properties of the synthesized particles were studied using TEM, XRD, AFM, VSM and PCS techniques. Mean particles size of the samples was between 4.5 and 10 nanometers, depending on experimental conditions. Effect ...

A second generation MRI contrast agent for imaging zinc ions in vivo.

A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.